Cozaar is used to treat arterial hypertension, protect the kidneys in type 2 diabetes mellitus with proteinuria, reduce the risk of associated cardiovascular diseases, as well as lower the death rate for hypertension, hypertrophy.
Cozaar
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Product Description
Cozaar (losartan) is a specific antagonist of angiotensin II receptors (subtype AT 1).Cozaar would not inhibit the kinase II enzyme, which catalyzes conversion reaction of angiotensin I to angiotensin II.
Cozaar decreases systemic vascular resistance (SVR), concentration of adrenalin and aldosterone in blood, hypertension, pressure of the pulmonary circuit; reduces afterload, provides urinative effect. Medication prevents myocardial hypertrophy, increases exercise tolerance in patients with cardiac decompensation (heart failure).
Safety information
Indications:
- Arterial hypertension.
- Congestive heart failure (in a combination therapy, in case of intolerance or ineffectiveness of angiotensin-converting-enzyme inhibitors (ACE inhibitors) therapy).
- Prevention of cardiovascular diseases (including stroke) and mortality in patients with arterial hypertension and left ventricular hypertrophy.
- Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension (it slows the progression of diabetic nephropathy to terminal chronic renal failure).
- Hypersensitivity to the components of the drug.
- Pregnancy
- Lactation
- Use in people under 18 years old (no data about effectiveness and safety )
How to use Cozaar
The drug is taken orally. You may take Cozaar with or without food. The medicine should be taken once a day. Average daily intake for patients with arterial hypertension is 50 mg. In some cases, in order to achieve better therapeutic effect, the dose should be increased to 100mg and is taken per day or in 2 divided doses.
Initial dose for patients with heart failure is 12,5 mg once a day. Typically, the dose is increased with a weekly interval (ie 12,5 mg per day, 25 mg per day, 50 mg per day) to average maintenance dose 50 mg per day depending on patient’s tolerance of the drug.
Side effects
Most commonly, there are no side effects for losartan. If any discovered, they have transient character, so in general, there is no need to cancel the treatment. Rarely, the following symptoms may arise: drowsiness, anxiety, memory disorders, depression, paresthesia, tremor, hypoaesthesia, migraine, hearing disorders, visual impairments, taste blindness, bronchitis, dyspnea, rhinitis, stomachache, nausea, diarrhea, backache, pain in limbs and chest; cramps, myalgia, persistent hypotension, tachycardia or bradycardia, stenocardia, arrhythmia, anemia.
Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
Brand Viagra - a drug from Pfizer, with a basic chemical called Sildenafil Citrate, is a first developed pharmaceutical to cure the difficulties with erection. It functions approximately within 4-5 hours, must be taken an hour prior to sex.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Claritin prevents development and facilitates the course of allergic reactions. Possesses antiallergic, antipruritic, antiexudative action. Reduces permeability of capillaries, controls oedemata of tissues, removes spasms of smooth muscles. It is prescribed at allergic rhinitis, conjunctivitis, pollinosis, urticaria fever, angioedema, pruritic dermatosis; pseudo-allergic reactions, caused by release of histamine; allergic reactions at stings of insects.
Cymbalta drug possesses a central mechanism of suppression of a pain syndrome that first of all can be noticed at increase in a threshold of painful sensitivity at pain syndrome of neuropathic etiology.
An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
Zyvox is a synthetic medicine with the increased antibacterial effectiveness. It is mostly used in the treatment of pulmonary and skin diseases caused by a wide range of Gram-positive species. In current medicinal practice, Zyvox often plays a role of the drug of last resort, since it is intended for use in people suffering from multidrug-resistant infections. The extremely high efficiency of this medicine makes it a popular choice in the treatment of severe bacterial infections and simultaneously limits its use against low-hazard infections in order to avoid propagation of resistant microorganisms.
Zithromax - antibiotic of a wide spectrum of action. Antibiotic-azalide, a representative of a new subgroup of macrolide antibiotics. In the focus of inflammation it has a bactericidal effect. For the active ingredient of Zithromax, Azithromycin, all the gram-positive cocci (except those bacteria which are resistant to erythromycin) are susceptible.
Viagra Plus is the latest form of the medical treatment which is known worldwide. The formula is intensified by active medicinal plants, causing a boundless feeling of potentiality, unlimited desire and infinite lasting. The ginseng is one of the main ingredients of Viagra Plus, which carries out stimulation and increases endocrine activity in an organism, strengthens metabolism and facilitates cordial activity, helping thereby an arterial flow of blood, stimulating think-tanks and is promoted also by simplification of functioning of the central nervous system. Erection, sexual desire, success of sexual intercourse are guaranteed. From 400 mg of Viagra Plus - 50 mg make sildenafit, the remained 350 mg are ginseng and vitamins.
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
Florinef is a brand name of Fludrocortisone. It is a corticosteroid produced to treat adrenogenital syndrome (also called Apera-Galle syndrome), Addison's disease, orthostatic hypotension, cerebral salt wasting syndrome, and adrenal insufficiency. The drug replenishes the deficiency of hormones of the adrenal cortex. 1 tablet contains 0.1 mg of fludrocortisone acetate. It participates in the metabolism, including mineral and carbohydrate one. The drug causes the retention of sodium ions and promotes the excretion of potassium.
An inhibitor of proton pump. The drug indications include: gastric ulcer and duodenal ulcer (in an acute phase), erosive gastritis, reflux-esophagit, Zolling-Erellison syndrome.
Nootropil improves cognitive processes, memory, attention, and mental performance.
Nootropilum affects the CNS, by changing the speed of propagation of the excitation in the brain, improves metabolic processes in nerve cells, improves by acting on the rheological characteristics of blood and causing no vasodilatory action.
Sustiva is an antiviral agent. A non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). It is based on efavirenz and is named like Sustiva by Bristol-Myers Squibb and United Drug.
The anti-malarial drug from the group of 8-aminohinolina derivatives. It is characterized by intercalation with DNA plasmodia, leading to disruption of nucleic acids synthesis. It demonstrates high activity against exo-erythrocytic forms of all types of malaria, including primary tissue and para- erythrocyte forms. Particularly active against primary tissue forms of Plasmodium falciparum.
An antispasmodic drug, which removes pain and reduces the tone of smooth muscles: gastrointestinal tract, biliary tract, uterus, it also relaxes the detrusor (direct antispasmodic and m-anticholinergic effect). Increases bladder capacity, reduces the frequency of detrusor contractions, hinders urination. Well tolerated when appointed for a long term. Used in neurogenic bladder (including detrusor hyperreflexia, multiple sclerosis or spina bifida), urinary incontinence (of idiopathic origin), nocturnal enuresis (in children older than 5 years).
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
Casodex - racemic mix, a nonsteroid anti-androgen which does not influence endocrine system in any way. The mechanism of effect of active component consists in its ability to contact androgenic receptors of "wild type" and to oppress the activity, thereby, bringing a prostate tumor into a regression stage. Casodex is taken as a medicine for monotherapy, and as a part of complex treatment (radiation).
Betahistine is diaminoxidase inhibitor - the enzyme inactivating histamine. Stabilizing the histamine which is formed in an organism, betahistine has a histamine-like effect. Drug is effective at peroral taking (by mouth). Drug expands precapillary sphincters of vessels of an inner ear, it improves microcirculation. The main use of betahistine has at Menyer's disease and similar diseases which are followed by dizziness attacks, a sonitus, a hearing impairment, nausea, vomiting.
Xalatan is a chemical analog of the hormone prostaglandin. It is a topical agent available in the form of eye drops with a concentration of latanoprost 50 mcg/ml. Its mode of action is similar to the one of its natural equivalent – the drug increases the flow of intraocular fluid from the hypertensive eyeball. As a result, the pressure in the eyeball slowly decreases. Since this symptom frequently accompanies various eye diseases, Xalatan is often prescribed in combination with other medicines. Today, this drug is among the high-priority agents in the treatment of such an ubiquitous disease as glaucoma.
Xenical - a powerful, specific and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine portion of the gastric and pancreatic lipases. The inactivated enzyme at the same time loses the ability to break down food fats coming in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the resulting decrease in the intake of calories into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
Fosamax - drug for treatment of Paget disease, osteoporosis at women in a postmenopause, osteoporosis at men, a hypercalcemia at malignant tumors. Active alendronate ingredient - non-hormonal specific inhibitor of an osteoclastic bone resorption, suppresses osteoclasts. Taking of Fosamax stimulates bone formation, recovers positive balance between a resorption and recovery of a bone, progressively increases the mineral density of bones, promotes formation of a normal bone tissue with normal histologic structure.
Alprostadil is a medicine used to treat the symptoms of Erectile Dysfunction (impotence).
Peripheral vasodilator with predominant effect on venous vessels. Reduces the need for myocardium in oxygen by reducing preload and afterload (reduces the end diastolic volume of the LV and reduces the systolic tension of its walls). Has the coronary dilatation effect. Reduces blood flow to the right atrium, helps to reduce pressure in the "small" circle of blood circulation and regression of symptoms with pulmonary edema. Promotes redistribution of coronary blood flow in the area with reduced blood circulation. Increases tolerance to physical activity in patients with IHD, angina pectoris.
Plaquenil (hydroxychloroquine) is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form.
Voltaren Gel is an over the counter and prescription medicine used to treat symptoms of actinic keratosis, osteoarthritis, acute pain and arthritis pain. Voltaren Gel may be used alone or with other medications.
Voltaren Gel belongs to a class of drugs called Topical Skin Products.
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