Diltiazem - has anti-anginal, antiarrhytmic and hypotensive effects. Reduces the intracellular maintenance of Ca2+ in cardiomyocytes and cells of smooth muscles of blood vessels, reduces heart rate, shows insignificant negative inotropic effect, improves a coronary, brain and renal blood flow.
Diltiazem
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Diltiazem Product Description
Drug Uses
Diltiazem is a medicine with antianginal, vasodilating and antihypertensive properties. Diltiazem is indicated for reducing the risk of cardiovascular events in adult patients with:
- mild to moderate hypertension
- chronic stable angina (including exertional angina)
- moderate to severe angina pectoris (effort angina)
Diltiazem is effective in treating various types of angina, including angina:
- in patients with normal ventricular function
- caused by atherosclerotic coronary artery disease
- without evidence of vasospasm or caused by coronary artery spasm
Maintenance Diltiazem dosage can vary greatly and usually do not exceed 360mg per day (single dose or in two divided doses).
Missed dose
If you missed the prescribed Diltiazem dosage, take this antianginal /antihypertensive agent as soon as possible. But skip the missed dose, if it is almost time for the next Diltiazem dose. Just resume the regular dosing schedule of Diltiazem.
More Information
Diltiazem may be administered in combination with other medicines for the cardiovascular diseases treatment, or in ineffectiveness or contraindications to alternative antianginal / antihypertensive therapy.
Storage
Diltiazem should be stored at room temperature of approximately 25°C. Protect from sunlight and excessive humidity.
Diltiazem Safety Information
Warnings
Diltiazem should be used with caution in patients with kidney failure or abnormal reduced liver function, because it can lead to reversible fatty liver disease. If drug-induced adverse skin reactions (incl. erythroderma) are observed in long-term Diltiazem therapy, this medicine should be discontinued.
Disclaimer
This review on Diltiazem is intended for general informational purposes, and can not answer personal health related questions about treatment of hypertension and angina. The information provided about the calcium-channel blocker Diltiazem is not intended to replace the attention or medical instructions from a cardiologist or other health care professional. The online pharmacy shall not be liable for any loss or damage, caused by improper use of the information on the antihypertensive and antianginal agent Diltiazem.
Diltiazem Side Effects
Serious adverse events of Diltiazem are extremely rare. The most serious of them include leg swelling. The anginal patients, taking Diltiazem, also report about: weakness, headache, nausea, costiveness, indigestion, gastric pain, atrioventricular block, leucopenia, palpitations, bradyarrhythmia, dizziness, rash, hives, malaise or erythema. The following adverse events are possible in less than 1% of patients taking Diltiazem: cardiac dysrhythmia, fainting, amnesia, depression, insomnia, somnolence, dry mouth, constipation, diarrhoea, parageusia, thirst, petechiae, itch, lazy eye, shortness of breath, or hyperuricemia.
Caduet consists of Amlodipine besylate and atorvastatin calcium. Caduet has a double mechanism of action; action of amlodipin as dihydropyridinic antagonist of calcium and for suppression of atorvastatin HMG-CoA reductase. It is taken for prevention of cardiovascular events at patients with hypertension, with three concurrent factors of cardiovascular risk, with cholesterol level from normal to moderately raised, without clinical manifestations of ischemic heart disease and also when according to the existing recommendations about treatment the combined use of amlodipin and low dose of atorvastatin is deemed appropriate.
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