Dapsone antibacterial agent, which is active concerning Mycobacterium leprae and tuberculosis. It has bacteriostatic action similar to antagonists of p-aminobenzoic acid.
Dapsone
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 100mg × 10 Pills | $5.12 | $51.21 + Bonus - 4 Pills | - | Add to cart |
| 100mg × 30 Pills | $3.65 | $109.50 + Bonus - 4 Pills | $44.10 | Add to cart |
| 100mg × 60 Pills | $3.28 | $196.93 + Bonus - 4 Pills | $110.40 | Add to cart |
| 100mg × 90 Pills | $3.16 | $284.36 + Bonus - 7 Pills Free Trackable Delivery | $176.40 | Add to cart |
| 100mg × 120 Pills | $3.10 | $371.79 + Bonus - 7 Pills Free Trackable Delivery | $242.40 | Add to cart |
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Dapsone product description
Dapsone is part of a group of substances called sulfones. The antibacterial result of Dapsone has the following mechanism, this substance, being a structural analog of para-aminobenzoic acid, interacts with dihydropyridine instead of para-aminobenzoic acid and competitively inhibits dihydropteroate synthetase. This prevents the synthesis of folic acid bacteria. Lack of folic acid, in turn, disrupts the formation of purines, pyrimidines and certain amino acids (methionine) of bacteria and, ultimately, leads to the cessation of bacterial growth. Dapsone has a bacteriostatic nature of the action, as it stops the growth and multiplication of bacteria, but does not cause their death.
Absorbed within 2-8 hours. It binds to plasma proteins by 70-90%, and the main metabolite of the drug - monoacetylldosone - by 99%. Metabolised in the liver to monoacetylldosone. Eliminated by the kidneys (70-85%) and through the gastrointestinal tract, 20% is excreted unchanged.
The drug is mainly used to treat leprosy and herpetiform dermatitis. During the treatment, it is necessary to perform a general blood test and monitor the liver transaminases, reticulocyte count, platelet count, methemoglobin concentration, urea nitrogen, creatinine. In addition, this medicine is designed for the treatment of tuberculosis, pneumonia caused by Pneumocystis carinii.
Dapsone safety information
The consumption of this medicine is oral. Dosing regimen is individual. As a part of combination therapy, this medical agent is used in a dosage of 50-100 mg/day or 1-2 mg/kg/day. If necessary, the maximum daily dosage is 300mg. The treatment procedure is long.
Among the contraindications, the manufacturer indicates hypersensitivity, incl. to sulfanilamides, a liver dysfunction, severe anemia, a deficiency of glucose-6-phosphate dehydrogenase or methemoglobin reductase (possibly the development of hemolytic anemia). The consumption of this medication during pregnancy and lactation is possible only for prevention therapy in patients with leprosy or herpetiform dermatitis.
Dapsone side effects
On the part of the blood: dose-dependent hemolysis with a growth in the level of hemoglobin and an growth in the amount of reticulocytes (in all patients), hemolytic anemia (pain in the back, legs, stomach area, loss of appetite, pallor of the skin, unusual fatigue or weakness, increase in body temperature), methemoglobinemia (cyanosis of the fingernails, lips or skin, shortness of breath, etc.), pathological changes in the blood (elevated body temperature, sore throat, unusual bleeding and hemorrhages, etc.), incl. agranulocytosis and hypoplastic anemia with fatal outcome, palpitation, cardialgia.
On the part of the skin: itching, dryness, redness or peeling of the skin, hair loss, toxic erythema, erythema multi-form, toxic epidermal necrolysis, nodular erythema, kore and scarlatina-like reactions.
On the part of the CNS and sensory organs: mental disorders, incl. mood changes, peripheral neuritis (sensation of numbness, tingling, burning, pain or weakness in the hands and feet), neurotoxicity (a headache, insomnia, nervousness).
On the part of allergic effects: skin rash, "sulphonic syndrome" (fever, malaise, exfoliative dermatitis, jaundice, lymphadenopathy, methemoglobinemia, anemia), usually develops after 6-8 weeks of therapy.
On the part of the digestive tract: liver damage (icterus sclera or skin), anorexia, nausea, vomiting.
Antidepressant; a specific inhibitor of serotonin reuptake by neurons of the brain. Has no stimulating or sedative effect, does not affect choline, muscarin-, histamine- and adrenergic processes. The therapeutic effect develops 1-4 weeks after the initiation of therapy.
Cialis Oral Jelly (Orange) - a new formula of Cialis which you can have, without washing down with water. Against background of ordinary drug it differs in increased influence speed. It is prescribed for improvement of sexual endurance of men during intimate proximity. It simplifies the excitative process of penis and strengthens erection. Noticeably increases duration of sexual intercourse. Besides, the drug possesses a pleasant orange flavor.
Viagra Oral Jelly - a new formula of the drug Viagra. Sildenafil - 100 mg. It is prescribed for men with a weak potentiality. Helps to recover libido and to improve sexual activity. Accelerates process of excitement of reproductive system. It makes erection brighter. Considerably increases duration of sexual intercourse. Besides, drug has various pleasant tastes, it is convenient to carry in a pocket or in a purse. Hurry to try it!
Cleocin has bacteriostatic and bactericidal activity depending on concentration of drug, infectious process and condition of an organism of the patient. Active against aerobic and anaerobic streptococcus (except for enterococci), the majority of staphylococcus except for methicillin-resistant strains, bacteroids except for Bacteroides melaninogenicus, spindle-shaped bacteria
Zantac - ranitidin - the drug is intended for the treatment of duodenal ulcers, benign gastric ulcer, postoperative ulcer, reflux esophagitis, Zollinger-Ellison syndrome, epigastric or chest pain. The administration of ranitidine is indicated in cases where a decrease in gastric secretion and a decrease in the production of hydrochloric acid is desirable, for the prevention of gastrointestinal bleeding, for the prevention of recurrence of bleeding in patients with bleeding ulcers of the stomach and duodenum, before general anesthesia in patients with a presumed risk of aspiration of acidic stomach contents (Mendelssohn syndrome), especially in women during childbirth delivery clashes.
Aciphex - the medicine, normalizing acidity of a stomach, inhibitor of a proton pomp. It is prescribed at gastroduodenal ulcer in the exacerbation phase, gastroesophageal reflux disease; states which are characterized by pathological hyper secretion including Zollinger-Ellison syndrome. In combination with bactericide - Helicobacter pylori eradication at patients with gastric ulcer or chronic gastritis; treatment and prevention of recurrence of an ulcer at patients with gastric ulcer related to Helicobacter pylori.
Zerit - treatment of infection caused by HIV, with severe clinical manifestations and ineffectiveness or intolerance of zidovudine, and other antiretroviral drugs. The nucleoside analogue of thymidine is phosphorylated by cellular enzymes to its active form - stavudine triphosphate. Suppresses reverse transcriptase of HIV, cellular DNA polymerases (beta and gamma), inhibits the synthesis of viral and mitochondrial DNA. It is active against HIV-1.
An antiaggregant, used for the prevention of thrombotic complications in patients with acute coronary syndrome (ACS), who are planned to undergo percutaneous coronary angioplasty and for prevention of stent thrombosis in acute coronary syndromes. The medicine is a receptor antagonist of P2Y12class to adenosine diphosphate (ADP), and consequently inhibits the activation and aggregation of platelets. Since platelets are involved in the development of atherosclerosis complications, the inhibition of platelet function may lead to a decrease in the frequency of cardiovascular complications.
is given to patients for treating severe acne that do not respond to other medicines
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
An anti-migraine drug. Used for emergency treatment to eliminate migraine, with aura as well. A selective agonist of 5-hydroxytryptamine 1D receptors. The effect can be observed within 30 minutes after the intake.
An antineoplastic, antiestrogen remedy. Used to treat breast cancer, mammary gland cancer, carcinoma in situ of the ductal breast cancer; endometrial cancer; estrogenconsisting tumors; adjuvant treatment of breast cancer. It inhibits estrogen receptors competitively in the target organs and tumors originating from these organs.
